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Zepbound: In the 72-week SURMOUNT-1 clinical trial, the following results were observed for different dosages of Zepbound when compared to a placebo: 5 mg/week: 16% weight loss or an average reduction of 35.5 lb (16.1 kg) 10 mg/week: 21.4% weight loss or an average reduction of 48.9 lb (22 kg) 15 mg/week: 22.5% weight loss or an average reduction of 52 lb (23.6 kg) Placebo: 2.4% weight loss or an average reduction of 5.3 lb (2.4 kg) Furthermore, after 72 weeks, between 85% to 91% of those on Zepbound achieved a body weight reduction of 5% or more, compared to only 35% on placebo

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It may exist both with and without copper binding, with copper affinity appearing to play a role in biological signaling

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